Their tails up after a morale-boosting win in the opener, a confident Indian women team would look to seal the three-match series against world champions England.
With the recent win, Pakistan overtook West Indies in the ICC Women's Championship table and jumped from sixth to fourth place.
India women ODI captain Mithali Raj recently led India to a 2-1 series win against New Zealand, something which she felt has given her side a lot of confidence.
This marks the first visit by any West Indies team to the country in 15 years.
Cricket West Indies named Merissa Aguilleira as the replacement skipper for the T20Is.
Merissa Aguilleira, Taylor’s predecessor, will captain the side as Taylor will join the team in Dubai when Windies face Pakistan in ICC Women's Championship games.
The Karachi visit will be West Indies women’s cricket team’s first tour in 15 years.
Fareeha Mehmood, Ghulam Fatima, Maham Tariq, and Rameen Shamin lost their contracts while Omaima Sohail was the new face in the contract list.
The two teams will also face-off in a three-match T20 International series in Guwahati starting March 4.
The three ODIs will be played on February 22, 25 and 28 at either the Wankhede Stadium or the Brabourne Stadium.