The spin duo of Iqbal Abdulla and Vishal Dabholkar shared nine wickets between them.
The Mumbai-Gujarat contest at Valsad is nearing an intriguing finish.
Gujarat placed themselves in a strong position as they first took a 99-run first innings lead.
Mumbai suffered an unexpected batting collapse to be all out for 154 against Gujarat.
Left-arm spinner Vishal Dabholkar shone with a four-wicket haul as Mumbai demolished Punjab by 180 runs to register their second successive win in the Ranji Trophy on Sunday.
West Indies captain Darren Sammy said he was ecstatic after scoring the winning runs that propelled Sunrisers Hyderabad into the playoffs of the Indian Premier League (IPL) 2013.
Assam's dream run in the Vijay Hazare Trophy continued as they stunned Ranji Trophy champions Mumbai by 27 runs to enter the semi-finals of the domestic ODI tournament at Vishakapatnam on Thursday.
Siddhesh Lad slammed an unbeaten 91-ball 115 while pacer Kshemal Waingankar shone with a five-wicket haul as Mumbai thrashed Saurashtra by 126 runs in their Vijay Hazare Trophy (West Zone) match, on Sunday.
Left-arm spinners Iqbal Abdulla and Ankeet Chavan took three each as Ranji champions Mumbai defeated Baroda by 17 runs in their limited-overs Vijay Hazare Trophy (West Zone) match at Pune on Thursday.
A star-studded Reliance 1 slumped to a four-wicket defeat against hosts Dr D Y Patil 'A' in the final of the T20 Cup in Navi Mumbai on Monday.