South Africa made two changes, all-rounders Wiaan Mulder and Dwaine Pretorius for batsman David Miller and fast bowler Beuran Hendricks.
The Johannesburg match will be the showpiece Pink ODI and history backs the Proteas.
Uncapped fast bowler Lutho Sipamla was on Friday named in a 14-man South African squad for three Twenty20 internationals against Pakistan early next month.
The 23-year-old is set to be given the entire February off before Sri Lanka arrive.
South Africa could score only 76 runs in the last 60 deliveries in the series opener and never looked to threaten the Pakistan bowlers.
Ravichandran Ashwin and Ravindra Jadeja are the best-ranked Indians in the bowlers' list at fifth and ninth place respectively.
Van der Dussen, 29, has featured for the South African Twenty20 international team.
Kagiso Rabada has said defended the surfaces saying scoring runs in Test cricket shouldn't be an easy prospect.
Pakistan were bowled out in the last over of the third day for 294 on Saturday, leaving South Africa 41 runs to win.
Facing a first innings deficit of 254 runs, Pakistan were 37 for two at lunch, still needing 217 runs to make South Africa bat again.