The first Test of the series in Rawalpindi marked the return of Test cricket in Pakistan, but it ended in a draw after being spoiled by bad weather.
The development means PSL will go off air unless the PCB brings in an alternate production services.
Pakistan is on a long road to revive international cricket following six years of isolation from 2009 to 2015.
Karachi was deprived of quality cricket for nine long years. Finally, the PSL 2018 final went underway and Islamabad United pulled off an all-round show to win the title for the second time
Pakistan Super League 2018 will see Islamabad United take on Peshawar Zalmi in the final on Sunday.
Pakistans flamboyant allrounder Shahid Afridi wants to play the final of the third Pakistan Super League as it will be held in his adopted hometown.
Karachi, the country's largest city, last hosted an international match in February 2009 -- a Test between Pakistan and Sri Lanka -- a week before the Lahore attack.
Pakistan Super League (PSL) 2018 will commence from February 22 with Peshawar Zalmi taking on Multan Sultans.
The Pakistan Cricket Board (PCB) is now mulling to host the final of the 2018 at the National Stadium in Karachi.
PCB chairman Najam Sethi has said the board is looking to get the Karachi's National Stadium ready in time for PSL 2018.