David Warner and Steven Smith returning will cause headaches for Australia's selectors.
Aaron Finch's team has now won eight consecutive ODI games to surge towards the World Cup.
Glenn Maxwell knocked three sixes and nine boundaries in his 98 off 82 balls to lift Australia -- sent into bat by Pakistan -- from 140-5 to an imposing total of 277.
Australia, meanwhile, brought in fast bowlers Kane Richardson and Nathan Coulter-Nile in place of Pat Cummins and Jason Behrendorff.
Australia hold an unassailable series lead and now will target their first 5-0 sweep since 2012.
The selectors have chosen to give Cummins time off, with the ODI series against Pakistan won.
Glenn Maxwell's scored 71 off 55 balls to set up Australia's 80-run win against Pakistan in the third ODI.
Finch and Maxwell starred with the bat before Zampa and Cummins shone with the ball.
Australia, who lead the five-match series 2-0,, will be eager to win the match and clinch the series with two games to spare.
Pakistan also made two changes, bringing in fast bowlers Usman Shinwari and Junaid Khan -- for their first games of the series -- in place of Faheem Ashraf and Mohammad Abbas.