Although Harrison admitted there were risks with the approach and that things "won't be perfect" but said it was a necessary trade-off to ensure the players' mental health is safeguarded.
Indian team wants to play two warm-up matches before the Test series against England.
Right before the 2021 T20 World Cup in India, England will be in Pakistan for a short two-match T20I series in October.
Michael Holding accused England bosses and Australia captain Aaron Finch of making "lame" statements over ending the practice of taking a knee.
International cricket is also set to return next month with England hosting West Indies for a three-match Test series.
ECB has already stated the Hundred will make a loss of 7million in its first five season.
Harrison said even if Britain's lockdown eased to allow cricket, games would likely be played behind closed doors, a concept he said the ECB were "starting to get comfortable with".
The Hundred is a new tournament consisting of eight city-based franchise sides, breaking away from the traditional county system.
England cricket chiefs have rallied round Ben Stokes after he criticised a British newspaper report about a family tragedy.
With flat tracks expected during a hot English summer, 500-run total for the first time may just not be out of reach.