First innings wreckers-in-chief, pacers Shardul Thakur (4/47) and Tushar Deshpande (4/53) were again the main destroyers in the visitors second innings
Pace bowlers Shardul Thakur (4 for 32) and Tushar Deshpande (5 for 46) got on top of the rival batsmen soon after Mumbai inserted Chhattisgarh in.
Mumbai used as many as eight bowlers in the day but barring Dhurmil Matkar (3-92) all others had an off day.
Mumbai face a daunting task when they take on Ranji Trophy champions Vidarbha in Nagpur from Saturday in a must-win Elite Group A game.
Kulkarni, who missed the last three games due to swelling in his ankle, had undergone rehabilitation at the National Cricket Academy in Bengaluru and was declared fit.
The four-day game will be played from December 30 at the Vidarbha Cricket Association Stadium at Jamtha, Nagpur.
While Mumbai took the first innings lead against Railways and grabbed three points, they settled for a point against Karnataka after conceding the first innings lead.
Mumbai and Karnataka are on the eighth and ninth spots respectively.
Mumbai pacer Tushar Deshpande suffered from a chronic problem of bowling frequent no-balls but it looks he has found a solution to that.
The outgoing Mumbai captain believes Dhawal Kulkarni, Shivam Dubey, Tushar Deshpande and Shams Mulani can bowl the team to success.