Pakistan were unable to walk away with a series win as South Africa triumphed in all three formats on the tour.
South Africa won the series against Pakistan 2-1, adding to a 3-0 success in a 3-match Test series and a 3-2 win in a 5-match
Seven Pakistan batsmen reached double figures, but the highest score was 26 by Mohammad Rizwan.
Pakistan made two changes, with Faheem Ashraf and Mohammad Amir returning at the expense of Hasan Ali and Usman Shinwari.
Yuzvendra Chahal, Bhuvneshwar Kumar and Kedar Jadhav have also made gains.
Pakistan had not lost a T20 series since they were eliminated from the World T20 in India in March 2016.
Miller slammed 65 not out off 29 balls.
Malik said left-arm fast bowler Shaheen Shah Afridi will replace Faheem Ashraf in the Pakistan team.
South Africa ended a nine-match Pakistan T20 winning streak in the first international at Newlands.
Pakistan captain Shoaib Malik said he did not expect the pitch to change much.
De Kock slammed 83 off 58 balls as South Africa chased down a target of 241 with seven wickets and ten overs to spare to
Fakhar was fourth out after a 73-ball innings when the total was 128 in the 25th over.
South Africa made two changes, all-rounders Wiaan Mulder and Dwaine Pretorius for batsman David Miller and fast bowler Beuran Hendricks.
Sarfraz was banned for four matches for his racial remarks against South Africa’s Andile Phehlukwayo.
Akram, who is also on the PCB's cricket committee, was clear that Sarfaraz should remain the national team's captain.
Pakistan vs South Africa - 1st Test
Pakistan
Match begins at 10:30 IST (05:00 GMT)
Afghanistan vs Ireland - 3rd ODI
Afghanistan
Match begins at 11:30 IST (06:00 GMT)
05 Feb, 2021 09:30 IST
MA Chidambaram Stadium, Chennai
Bangladesh vs West Indies - 1st Test
03 Feb, 2021 09:00 IST
Zahur Ahmed Chowdhury Stadium, Chattogram
Pakistan vs South Africa - 2nd Test
04 Feb, 2021 10:30 IST
Rawalpindi Cricket Stadium, Rawalpindi
Afghanistan vs Ireland - 3rd ODI
26 Jan, 2021 11:30 IST | 06:00 GMT
Sheikh Zayed Stadium, Abu Dhabi
Bangladesh vs West Indies - 1st Test
03 Feb, 2021 09:00 IST | 03:30 GMT
Zahur Ahmed Chowdhury Stadium, Chattogram
Bangladesh vs West Indies - 2nd Test
11 Feb, 2021 09:00 IST | 03:30 GMT
Shere Bangla National Stadium, Mirpur
Afghanistan vs Ireland - 2nd ODI
Afghanistan beat Ireland by 7 wickets
Bangladesh vs West Indies - 2nd ODI
Bangladesh beat West Indies by 7 wickets
Afghanistan vs Ireland - 1st ODI
Afghanistan beat Ireland by 16 runs
Bangladesh vs West Indies - 1st ODI
Bangladesh beat West Indies by 6 wickets
India beat Australia by 3 wickets